| Autor: |
Tim Cadman, Ahmed Elhakeem, Johan Lerbech Vinther, Demetris Avraam, Paula Carrasco Espi, Lucinda Calas, Marloes Cardol, Marie-Aline Charles, Eva Corpeleijn, Sarah Crozier, Montserrat de Castro, Marisa Estarlich, Amanda Fernandes, Serena Fossatti, Dariusz Gruszfeld, Kathrin Gurlich, Veit Grote, Sido Haakma, Jennifer R. Harris, Barbara Heude, Rae-Chi Huang, Jesús Ibarluzea, Hazel Inskip, Vincent Jaddoe, Berthold Koletzko, Sandrine Lioret, Veronica Luque, Yannis Manios, Giovenale Moirano, George Moschonis, Johanna Nader, Mark Nieuwenhuijsen, Anne-Marie Nybo-Andersen, Rosmary McEachen, Angela Pinot de Moira, Maja Popovic, Theodosia Salika, Theano Roumeliotaki, Loreto Santa Marina, Susana Santos, Sylvain Serbert, Evangelia Tzorovili, Marina Vafeiadi, Elvira Verduci, Martine Vrijheid, Marieke Welten, John Wright, Tiffany C Yang, Daniela Zugna, Deborah Lawlor |
| Rok vydání: |
2022 |
| Popis: |
BackgroundInternational sharing of cohort data for research is important and challenging. The LifeCycle project aimed to harmonise data across birth cohorts and develop methods for efficient federated analyses of early life stressors on offspring outcomes.AimTo explore feasibility of federated analyses of associations between four different types of pregnancy exposures (maternal education, area deprivation, proximity to green space and gestational diabetes) with offspring BMI from infancy to 17 years.MethodsWe used harmonised exposure and outcome data from 17 cohorts (n=200,650 mother-child pairs) from the EU Child Cohort Network. For each child, we derived BMI at five age periods: (i) 0-1 years, (ii) 2-3, (iii) 4-7, (iv) 8-13 and (v) 14-17 years. Associations were estimated using linear regression via one-stage individual participant data meta-analysis using the federated analysis platform DataSHIELD.ResultsAssociations between lower maternal education and higher child BMI emerged from age 4 years and increased with age (difference in BMI z-score comparing low with high education age 0-1 years = 0.02 [95% CI 0.00, 0.03], 2-3 years = 0.01 [CI -0.02, 0.04], 4-7 years = 0.14 [CI 0.13, 0.16], 8-13 years = 0.22 [CI 0.20, 0.24], 14-17 years = 0.20 [CI 0.16, 0.23]). A similar pattern was found for area deprivation. Gestational diabetes was positively associated with BMI from 8 years (8-13 years = 0.17 [CI 0.10, 0.24], 14-17 years = 0.012 [CI -0.13, 0.38]) but not at younger ages. The normalised difference vegetation index measure of maternal proximity to green space was weakly associated with higher BMI in the first year of life but not at older ages.ConclusionsAssociations between maternal education, area-based socioeconomic position and GDM with BMI increased with age. Maternal proximity to green space was not associated with offspring BMI, other than a weak association in infancy. Opportunities and challenges of cross-cohort federated analyses are discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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