Cerebrospinal-fluid profile in neuroborreliosis and its diagnostic significance
| Autor: | J. Bednářová |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pathology
medicine.medical_specialty Igm antibody Microbiology Diagnosis Differential Cerebrospinal fluid Borrelia burgdorferi Group Cytology Medicine Humans Lyme Neuroborreliosis Medical history Serum Albumin Cerebrospinal Fluid biology business.industry Histocytochemistry Albumin General Medicine medicine.disease Antibodies Bacterial Immunoglobulin M Blood-Brain Barrier Immunoglobulin G Immunology biology.protein Csf analysis Antibody Nervous System Diseases business Neuroborreliosis |
| Zdroj: | Folia microbiologica. 51(6) |
| ISSN: | 0015-5632 |
| Popis: | Selected cerebrospinal-fluid (CSF) parameters (intrathecal synthesis ofBorrelia-specific antibodies, oligoclonal IgG bands, CSF-to-serum quotient of albumin as a marker of blood-CSF barrier function and cytology) and typical CSF profile in neuroborreliosis were evaluated with the aim of elucidating possible clinical and laboratory similarities of neuroborreliosis (NB) and other neurological diseases (OND). From the cohort of 58 patients (38 diagnosed for NB, 20 with OND) NB patients had positiveBorrelia-specific IgG antibodies in 97 % and positiveBorrelia-specific IgM antibodies in 55 %; oligoclonal IgG bands were detected in 55 %. The blood-CSF barrier was impaired in 89 %, positive cytology was detected in 97 % of the NB patients. Evaluation of specific intrathecal synthesis improves CSF diagnosis of NB, therefore, a combined CSF analysis has to be considered along with the clinical picture and medical history when formulating the diagnosis of NB. |
| Databáze: | OpenAIRE |
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