Secretory Carcinoma of the Breast: Clinicopathologic Profile of 14 Cases Emphasizing Distant Metastatic Potential
| Autor: | Britta Weigelt, Jorge S. Reis-Filho, Fresia Pareja, Edi Brogi, Hannah Y Wen, Gouri Nanjangud, Melissa Murray, Raza S Hoda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Adult Male medicine.medical_specialty Histology medicine.medical_treatment Sentinel lymph node Breast Neoplasms Article Pathology and Forensic Medicine Targeted therapy 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Biopsy Progesterone receptor medicine Humans Neoplasm Metastasis Child Pathological Basal-like carcinoma medicine.diagnostic_test business.industry Carcinoma General Medicine Middle Aged medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Female Breast carcinoma business Secretory Breast Carcinoma |
| Zdroj: | Histopathology |
| Popis: | Aims Secretory carcinoma of the breast (SCB) is a rare histological type of breast carcinoma with a generally indolent clinical behaviour. We aim to elucidate the clinical, pathological and molecular findings of SCB cases and identify characteristics associated with aggressive clinical courses. Methods and results Fourteen patients with SCB were identified, including 12 women and two men, with a median age of 56 years (range = 8-81 years). Clinical data, histological diagnosis, molecular findings and follow-up were reviewed. Eight patients presented with palpable masses and four patients with radiographic abnormalities. All cases were unilateral. Surgical procedures included excisional biopsies and ipsilateral mastectomies. In 10 cases, oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) results were obtained, with six cases positive for ER and three positive for PR. All cases lacked HER2 overexpression. Sentinel lymph node biopsy was performed in 10 cases, and two patients had axillary lymph node metastasis. Follow-up ranged from 21 to 212 months (median = 70 months). Two patients developed distant metastasis of SCB. Molecular analysis of these aggressive tumours revealed amplification of the 16p13.3 locus, a TERT promotor mutation and loss of 9p21.3 locus. Review of the literature for SCB cases with distant metastasis was performed. Conclusions Although SCBs are generally associated with a favourable prognosis, our study and review demonstrate that a subset of SCBs may develop distant metastases. Further studies are warranted to identify markers predictive of more aggressive clinical behaviour in this rare breast cancer subtype. |
| Databáze: | OpenAIRE |
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