Peptide Recognition of Cholesterol in Fluid Phospholipid Bilayers
| Autor: | Masaru Mukai, Steven L. Regen, Martin R. Krause |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Models
Molecular chemistry.chemical_classification 1 2-Dipalmitoylphosphatidylcholine Cholesterol Lipid Bilayers technology industry and agriculture Phospholipid Peptide General Chemistry Biochemistry Catalysis Sterol Amino acid chemistry.chemical_compound Colloid and Surface Chemistry Membrane chemistry lipids (amino acids peptides and proteins) Peptides Lipid bilayer Phospholipids |
| Zdroj: | Journal of the American Chemical Society. 137:12518-12520 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/jacs.5b08132 |
| Popis: | N-Acetyl-LWYIKC-amide, a cholesterol recognition/interaction amino acid consensus (CRAC) peptide, has been found capable of recognizing an exchangeable form of cholesterol in liquid-disordered (l(d)) bilayers derived from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). In sharp contrast, such recognition is barely detectable in analogous cholesterol-rich, liquid-ordered (l0) bilayers. These findings represent the first evidence for a peptide favoring a sterol as a nearest-neighbor in fluid bilayers. They also reveal that such recognition can be strongly dependent on the degree of compactness of the membrane. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|