Sodium Hydrosulfide Prevents Myocardial Dysfunction through Modulation of Extracellular Matrix Accumulation and Vascular Density
| Autor: | Yi-Zhun Zhu, Xian Li Wang, Xi-Ling Wang, Li-Long Pan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Myocardial Infarction hydrogen sulfide Rats Sprague-Dawley lcsh:Chemistry chemistry.chemical_compound Fibrosis Myocardial infarction lcsh:QH301-705.5 Spectroscopy remodeling Cardioprotection Ventricular Remodeling General Medicine Extracellular Matrix Computer Science Applications Vascular endothelial growth factor Vascular endothelial growth factor A Matrix Metalloproteinase 9 cardioprotection neovascularization Cardiac function curve medicine.medical_specialty infarction Neovascularization Physiologic Sodium hydrosulfide Sulfides Article Catalysis Inorganic Chemistry Internal medicine medicine Animals Physical and Theoretical Chemistry Ventricular remodeling Collagen Type II Molecular Biology Organic Chemistry Cystathionine gamma-Lyase medicine.disease Actins Rats Collagen Type III Endocrinology chemistry lcsh:Biology (General) lcsh:QD1-999 Heme Oxygenase-1 |
| Zdroj: | International Journal of Molecular Sciences, Vol 15, Iss 12, Pp 23212-23226 (2014) International Journal of Molecular Sciences Volume 15 Issue 12 Pages 23212-23226 |
| ISSN: | 1422-0067 |
| Popis: | The aim was to examine the role of exogenous hydrogen sulfide (H2S) on cardiac remodeling in post-myocardial infarction (MI) rats. MI was induced in rats by ligation of coronary artery. After treatment with sodium hydrosulfide (NaHS, an exogenous H2S donor, 56 μM/kg·day) for 42 days, the effects of NaHS on left ventricular morphometric features, echocardiographic parameters, heme oxygenase-1 (HO-1), matrix metalloproteinases-9 (MMP-9), type I and type III collagen, vascular endothelial growth factor (VEGF), CD34, and α-smooth muscle actin (α-SMA) in the border zone of infarct area were analyzed to elucidate the protective mechanisms of exogenous H2S on cardiac function and fibrosis. Forty-two days post MI, NaHS-treatment resulted in a decrease in myocardial fibrotic area in association with decreased levels of type I, type III collagen and MMP-9 and improved cardiac function. Meanwhile, NaHS administration significantly increased cystathionine γ-lyase (CSE), HO-1, α-SMA, and VEGF expression. This effect was accompanied by an increase in vascular density in the border zone of infarcted myocardium. Our results provided the strong evidences that exogenous H2S prevented cardiac remodeling, at least in part, through inhibition of extracellular matrix accumulation and increase in vascular density. |
| Databáze: | OpenAIRE |
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