7-Hydroxycoumarin−Hemicyanine Hybrids: A New Class of Far-Red Emitting Fluorogenic Dyes
| Autor: | Jean-Alexandre Richard, Pierre-Yves Renard, Anthony Romieu, Marc Massonneau |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Indoles
Chemistry Organic Chemistry Color Water Far-red Carbocyanines Photochemistry Biochemistry Fluorescence symbols.namesake chemistry.chemical_compound Penicillin G Acylase Solubility Cascade reaction Stokes shift symbols Phenol Penicillin Amidase Umbelliferones Physical and Theoretical Chemistry Fluorescent Dyes |
| Zdroj: | Organic Letters. 10:4175-4178 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | The design and synthesis of novel water-soluble far-red emitting phenol-based fluorophores derived from 7-hydroxycoumarin are described. These hemicyanine-coumarin hybrids display promising spectroscopic features such as large apparent Stokes shift (ranging from 60 to 140 nm) and fluorescence emission maxima between 620 and 720 nm in physiological conditions. Their utility was then illustrated by the preparation of an original fluorogenic probe of penicillin G acylase (PGA) whose fluorescence is unveiled through an enzyme-initiated domino reaction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|