Assessment of Longitudinal Reproducibility of Mice LV Function Parameters at 11.7 T Derived from Self-Gated CINE MRI
| Autor: | Zhi Zuo, Wolfgang Rottbauer, Detlef Stiller, Alireza Abaei, Genshan Ma, Anne Subgang, Volker Rasche |
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| Rok vydání: | 2017 |
| Předmět: |
Cardiac function curve
Article Subject Heart Ventricles lcsh:Medicine Magnetic Resonance Imaging Cine 030204 cardiovascular system & hematology Ventricular Function Left General Biochemistry Genetics and Molecular Biology 030218 nuclear medicine & medical imaging Left ventricular mass Mice 03 medical and health sciences 0302 clinical medicine medicine Animals Myocardial infarction Lv function Reproducibility Ejection fraction General Immunology and Microbiology business.industry lcsh:R Reproducibility of Results Stroke Volume General Medicine Stroke volume medicine.disease Cine mri Female Nuclear medicine business Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2017 (2017) |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2017/8392952 |
| Popis: | The objective of this work was the assessment of the reproducibility of self-gated cardiac MRI in mice at ultra-high-field strength. A group of adult mice (n=5) was followed over 360 days with a standardized MR protocol including reproducible animal position and standardized planning of the scan planes. From the resulting CINE MRI data, global left ventricular (LV) function parameters including end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF), and left ventricular mass (LVM) were quantified. The reproducibility of the self-gated technique as well as the intragroup variability and longitudinal changes of the investigated parameters was assessed. Self-gated cardiac MRI proved excellent reproducibility of the global LV function parameters, which was in the order of the intragroup variability. Longitudinal assessment did not reveal any significant variations for EDV, ESV, SV, and EF but an expected increase of the LVM with increasing age. In summary, self-gated MRI in combination with a standardized protocol for animal positioning and scan plane planning ensures reproducible assessment of global LV function parameters. |
| Databáze: | OpenAIRE |
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