Reversal of the EHDP Inhibition of Calcium Absorption by 1,25-Dihydroxycholecalciferol
| Autor: | J.-P. Bonjour, H. Fleisch, L. A. Matejowec, Hector F. DeLuca, U. Trechsel, J. L. Omdahl |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Hypercalcaemia Clinical Biochemistry chemistry.chemical_element Calcium Biochemistry Intestinal absorption chemistry.chemical_compound Osteogenesis Internal medicine Vitamin D and neurology medicine Animals Vitamin D Calcium metabolism Vitamin D metabolism Hydroxycholecalciferols General Medicine Single injection medicine.disease Rats Endocrinology Intestinal Absorption chemistry Hypercalcemia Female Cholecalciferol |
| Zdroj: | European Journal of Clinical Investigation. 3:44-48 |
| ISSN: | 0014-2972 |
| DOI: | 10.1111/j.1365-2362.1973.tb00328.x |
| Popis: | Disodium ethane- 1 -hydroxy - 1,1 -diphosphonate (EHDP), given a t a dose of 10 mg of P kg-1 day-1 S.C. for 7 days to rats on a high calcium-high vitamin D diet, inhibits bone mineralisation, induces hypercalcaemia and decreases the intestinal calcium absorption. The intestinal response could be explained by an interference with vitamin D metabolism. To test this hypothesis, cholecalciferol (D,), 25-hydroxy-cholecnlciferol (25-OHD3) and 1,25-dihydrorycholecalciferol [1,25-(OH)2D3] were administered to EHDP-treated rats. A single injection of 325 pmoles of 1,25-(OH)2D3 completely reversed the EHDP-induced decrease in intestinal calcium absorption. No effect was observed when the same dose or a tenfold greater dose (3250 pmoles) of D2 or 25-OHD3 were administered or when these two compounds were given a t the dose of 6350 pmoles/day during the 7 days of EHDP treatment. These findings strongly suggest that the low calcium absorption rate observed in the EHDP-treated rats is due to a reduced conversion of 25-OHD3 to 1,25-(OH)2D3. The role of the EHDP-induced hypercalcaemia to account for this response remains to be established. |
| Databáze: | OpenAIRE |
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