Heritability of serum TSH, free T4 and free T3 concentrations: a study of a large UK twin cohort
| Autor: | Scott Wilson, Tim D. Spector, Mario Falchi, Gabriela L. Surdulescu, Suzanne J. Brown, Vijay Panicker, J. B. Richards, Ee Mun Lim, John P. Walsh, Stephen J. Fletcher |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Adolescent endocrine system diseases Endocrinology Diabetes and Metabolism Thyroid Gland Thyrotropin Endocrinology Thyroid-stimulating hormone Internal medicine Twins Dizygotic medicine Humans Aged Aged 80 and over Triiodothyronine business.industry Thyroid Twins Monozygotic Middle Aged Heritability United Kingdom Anti-thyroid autoantibodies Thyroxine medicine.anatomical_structure Pituitary Gland Cohort Female business hormones hormone substitutes and hormone antagonists Cohort study Hormone |
| Zdroj: | Clinical Endocrinology. 68:652-659 |
| ISSN: | 1365-2265 0300-0664 |
| DOI: | 10.1111/j.1365-2265.2007.03079.x |
| Popis: | Objective Thyroid hormone action influences many metabolic and synthetic processes, but the degree of regulation attributed to genes and environmental factors affecting normal variation remains controversial. Design We investigated the magnitude of the genetic and environmental determination of serum concentrations of free (f) T3, fT4, TSH and the fT4 x TSH product and their variation, in a large cohort of twin pairs. Female dizygous and monozygous twins (849 and 213 pairs, respectively) from the TwinsUK registry (mean age 45.5, range 18-80 years) were studied. Results Comparison of thyroid parameters within various groups showed no differences between smoking categories, and higher serum TSH and lower fT3 in subjects with positive thyroid antibodies. Using structural equation modelling, we estimated the heritable contribution to serum thyroid parameters (with 95% confidence intervals) to be 65% (58%-71%) for TSH, 65% (58%-71%) for the fT4 x TSH product, 39% (20%-55%) for fT4 and 23% (3%-41%) for fT3. Conclusions We conclude that genetic regulation is a particularly important determinant of TSH and the fT4 x TSH product, and is a less important determinant of fT4 and fT3 concentrations in Caucasian women. These data from a large well-characterized cohort suggest that while there is a strong heritable contribution to serum TSH, variation in fT4 and fT3 concentrations may be less explained by genetic factors and more driven by environmental effects than previously thought. |
| Databáze: | OpenAIRE |
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