Nitrile anion cyclization with epoxysilanes followed by brook rearrangement/ring opening of cyclopropane nitriles/alkylation

Autor:	Seigo Okugawa, Kei Takeda
Rok vydání:	2004
Předmět:	Nitrile Chemistry Stereochemistry Organic Chemistry General Medicine Brook rearrangement Alkylation Ring (chemistry) Cleavage (embryo) Biochemistry Medicinal chemistry Cyclopropane chemistry.chemical_compound Nitrile anion Physical and Theoretical Chemistry
Zdroj:	Organic letters. 6(17)
ISSN:	1523-7060
Popis:	The reaction of delta-silyl-gamma,delta-epoxypentanenitrile derivatives with a base and an alkylating agent affords delta-siloxy-gamma,delta-unsaturated pentanenitrile derivatives via a tandem process that involves the formation of the cyclopropane derivative by epoxy nitrile cyclization followed by Brook rearrangement and an anion-induced cleavage of the cyclopropane ring.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dca46b28338503c60752de9f604cc1b https://pubmed.ncbi.nlm.nih.gov/15330661 Zobrazit plný text záznamu