Dextran-Based Nanoparticles to Formulate pH-Responsive Pickering Emulsions: A Fully Degradable Vector at a Day Scale
| Autor: | Clémence Courrégelongue, Valentin Maingret, Valérie Héroguez, Véronique Schmitt |
|---|---|
| Přispěvatelé: | Centre de Recherche Paul Pascal (CRPP), Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie des Polymères Organiques (LCPO), Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC) |
| Rok vydání: | 2020 |
| Předmět: |
Polymers and Plastics
Dodecane Nanoparticle Bioengineering Pickering emulsions 02 engineering and technology bio-friendly vector modified polysaccharide 010402 general chemistry 01 natural sciences stimuli-responsive nanoprecipitation Biomaterials chemistry.chemical_compound Hydrolysis Drug Delivery Systems Materials Chemistry Acetone Dextrans [CHIM.MATE]Chemical Sciences/Material chemistry Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Environmentally friendly Pickering emulsion 0104 chemical sciences biocompatible systems Dextran chemistry Chemical engineering Nanoparticles Degradation (geology) Emulsions 0210 nano-technology [PHYS.COND.CM-SCM]Physics [physics]/Condensed Matter [cond-mat]/Soft Condensed Matter [cond-mat.soft] |
| Zdroj: | Biomacromolecules Biomacromolecules, American Chemical Society, 2020, 21 (12), pp.5358-5368. ⟨10.1021/acs.biomac.0c01489⟩ |
| ISSN: | 1526-4602 1525-7797 |
| DOI: | 10.1021/acs.biomac.0c01489 |
| Popis: | International audience; Biosourced Pickering emulsion stabilizers with stimuli responsiveness are mostly designed for recycling and do not offer fast degradability as required for drug-delivery applications. Herein, dextran-a hydrophilic and biofriendly polysaccharide obtainable from biomass recovery-was used for the first time as a brick material for the formulation of (bio)degradable pH-sensitive Pickering emulsions. It was first modified with hydrophobic acetals moieties to provide pH-sensitive acetalated dextran. Under acidic conditions, it degrades into three biocompatible (macro)molecules: dextran, ethanol and acetone. Nanoparticles of acetalated-dextran were obtained using the nanoprecipitation process and could be similarly fully hydrolyzed under acidic conditions within 6 h. Then, O/W Pickering emulsions of dodecane (model oil) and medium-chain triglyceride (biocompatible oil) were successfully stabilized using these nanoparticles. pH-induced destabilization of these Pickering emulsions (including nanoparticles degradation) took less than 24 h. Finally, neither accumulation of nanoparticles nor harmful components release happened during the process, making this stimuliresponsive vector safe and environmentally friendly. |
| Databáze: | OpenAIRE |
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