Is the mechanism of COVID-19 coagulopathy still a rabbit’s hole?

Autor:	Ganesh Keshav Thirunavukkarasu, Ashna Rajan, Richard F. Lockey, Narasaiah Kolliputi
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	0301 basic medicine 2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Complement ACE2 macromolecular substances Bioinformatics Biochemistry 03 medical and health sciences 0302 clinical medicine Von Willebrand factor Coagulopathy medicine Molecular Biology Thromboinflammation biology business.industry Mechanism (biology) COVID-19 Cell Biology medicine.disease Complement system BITS and BYTES 030104 developmental biology 030220 oncology & carcinogenesis SARS-CoV2 biology.protein business
Zdroj:	Journal of Cell Communication and Signaling
ISSN:	1873-961X 1873-9601
Popis:	The pathophysiology of COVID-19 is an enigma with its severity often determined by the extent of coagulopathy. Several regulatory pathways targeted by the SARS-CoV-2 include the renin-angiotensin system, von Willebrand Factor, and most importantly, the complement pathway. This article discusses these pathways to help design potential future therapies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc774241b13279ae0e4537fdbaa05ce http://europepmc.org/articles/PMC8170857 Zobrazit plný text záznamu Full text from SpringerLink