Laxative potency and acute toxicity of some anthraquinone derivatives, senna extracts and fractions of senna extracts
| Autor: | Heli Lainonen, Pentti Hietala, Martti Marvola, Tuuli Parviainen |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Senna
Health Toxicology and Mutagenesis medicine.medical_treatment Laxative Anthraquinones Toxicology 030226 pharmacology & pharmacy Median lethal dose Sennosides Lethal Dose 50 03 medical and health sciences Mice 0302 clinical medicine medicine Potency Animals Pharmacology biology Traditional medicine Cathartics Senna Extract digestive oral and skin physiology biology.organism_classification Acute toxicity 3. Good health 030220 oncology & carcinogenesis Toxicity Anthraquinone Derivatives Female |
| Zdroj: | Pharmacologytoxicology. 61(2) |
| ISSN: | 0901-9928 |
| Popis: | This paper investigates the laxative effect and acute toxicity of certain fractions of senna extracts in mice. The same tests were also carried out with several pure anthraquinone derivatives common in senna pods. The results show that the laxative and toxic components of senna pods and senna extracts can be separated. The most potent laxative components, sennosides A + B and Fraction V (relative potencies 1 and 0.9 respectively), have the lowest toxicity (relative intravenous toxicities 1 and less than 1). Fractions with very low laxative activity (rhein-8-glucoside and Fraction IV, relative potencies 0.56 and 0.05) have the highest acute toxicity (relative toxicities 10 and 32 respectively). |
| Databáze: | OpenAIRE |
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