Sunscreens containing physical UV blockers can increase transdermal absorption of pesticides
| Autor: | Rhonda M. Brand, Roselyn M Wilson, James Pike, Anna R. Charron |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
0301 basic medicine
Health Toxicology and Mutagenesis Administration Topical DEET Absorption (skin) 010501 environmental sciences Toxicology medicine.disease_cause 01 natural sciences Absorption 03 medical and health sciences chemistry.chemical_compound Mice medicine Organic chemistry Animals Drug Interactions Coloring Agents 0105 earth and related environmental sciences Transdermal Titanium Mice Hairless 030102 biochemistry & molecular biology Herbicides Public Health Environmental and Occupational Health Penetration (firestop) Solvent Parathion chemistry Insect Repellents Titanium dioxide Female 2 4-Dichlorophenoxyacetic Acid Zinc Oxide Insect repellent Sunscreening Agents Ultraviolet Nuclear chemistry |
| Zdroj: | Toxicology and industrial health. 19(1) |
| ISSN: | 0748-2337 |
| Popis: | People are encouraged to wear sunscreens because of their effectiveness at reducing the risk of skin cancer. The dermal penetration of the herbicide 2,4-D can be enhanced by commercial formulations containing chemical ultraviolet (UV) absorbers, the absorbers themselves and the insect repellent DEET. This work has been extended to determine whether commercially available sunscreens containing the physical UV absorbers titanium dioxide (TiO2) or zinc oxide (ZnO) enhance the transdermal absorption of pesticides. Hairless mouse skin was pretreated with either commercially available sunscreens or the UV absorbers themselves, dissolved in phenyl trimethicone. In vitro permeability studies were performed with the pesticides 2,4-D, paraquat, parathion or malathion. The data demonstrate that pretreatment with five of the nine sunscreens tested increased the transdermal absorption of 2,4-D ( P 2 had no effect. Combining UV absorbers in the presence of trimethicone resulted in ‘sunscreens’ that could actually inhibit 2,4-D penetration. Inert ingredients therefore control the increased absorption seen in commercial sunscreen products and this enhancement can be eliminated by substituting phenyl trimethicone as the solvent. Sunscreen use must still be encouraged even with the undesirable side effect of increased penetration through the skin. |
| Databáze: | OpenAIRE |
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