Maternal versus paternal living kidney transplant donation is associated with lower rejection in young pediatric recipients: A Collaborative Transplant Study report
| Autor: | Géraldine L. Engels, Burkhard Tönshoff, Caner Süsal, Ingo Müller, Anne Kruchen, Jun Oh, Bernd Döhler |
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| Rok vydání: | 2021 |
| Předmět: |
Graft Rejection
Male Parents Pediatrics medicine.medical_specialty Adolescent Kaplan-Meier Estimate Risk Factors Living Donors medicine Humans Registries Organ donation Child Kidney transplantation Proportional Hazards Models Retrospective Studies Transplantation Pregnancy business.industry Proportional hazards model Graft Survival Hazard ratio Age Factors Infant Microchimerism medicine.disease Kidney Transplantation Child Preschool Donation Pediatrics Perinatology and Child Health Kidney Failure Chronic Female business Kidney disease |
| Zdroj: | Pediatric Transplantation. 26 |
| ISSN: | 1399-3046 1397-3142 |
| DOI: | 10.1111/petr.14154 |
| Popis: | BACKGROUND Approximately 1700 children per year with end-stage kidney disease undergo kidney transplantation in Europe and the United States of America; 30%-50% are living donor kidney transplantations. There may be immunological differences between paternal and maternal donors due to transplacental exchange of cells between the mother and fetus during pregnancy leading to microchimerism. We investigated whether the outcome of living-related kidney transplantation in young children is different after maternal compared with paternal organ donation. METHODS Using the international Collaborative Transplant Study (CTS) database, we analyzed epidemiological data of 7247 children and adolescents aged |
| Databáze: | OpenAIRE |
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