Chimpanzee CXCR4 and CCR5 Act as Coreceptors for HIV Type 1
| Autor: | Jean-Luc Pretet, Annette C. Zerbib, Marc Girard, Jean-Gérard Guillet, Cécile Butor |
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| Rok vydání: | 1997 |
| Předmět: |
Receptors
CXCR4 DNA Complementary Pan troglodytes Receptors CCR5 viruses Molecular Sequence Data Immunology CXCR4 Virus Chemokine receptor Virology medicine Animals Humans Amino Acid Sequence Receptor Peptide sequence Immunodeficiency Genetics Base Sequence biology Nucleic acid sequence virus diseases biology.organism_classification medicine.disease Infectious Diseases Lentivirus HIV-1 |
| Zdroj: | AIDS Research and Human Retroviruses. 13:1583-1587 |
| ISSN: | 1931-8405 0889-2229 |
| Popis: | Chemokine receptors are molecules involved in the fusion of immunodeficiency viruses after their attachment. As chimpanzees are the animal model for infection by HIV-1, we cloned and sequenced chimpanzee CXCR4 and CCR5 from PBMCs. Chimpanzee CXCR4 was found to be identical to human CXCR4, which provides an explanation for the sensitivity of chimpanzees to lymphotropic isolates of HIV-1. Chimpanzee CCR5 showed two substitutions with respect to human CCR5. However, we show that the macrophage-tropic isolate HIV-1-Ba-L can use chimpanzee CCR5 as a fusion receptor. Therefore, the resistance of chimpanzee PBMCs to infection by macrophage-tropic isolates of HIV-1 is unlikely to be due to substitutions in CCR5. |
| Databáze: | OpenAIRE |
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