Basotest and suxamethonium allergy

Autor: S. Atkinson, I. M. Aly Hassan, J. D. M. Edgar, A. D. Crockard, M. S. Asghar
Rok vydání: 2001
Předmět:
Zdroj: Allergy. 56(10)
ISSN: 0105-4538
Popis: THE identification of the drugs causing anaesthesia-induced adverse reactions is problematic and dependent on clinical history, detection of specific IgE antibodies, and skin testing. Flow cytometric assessment of drug-induced basophil activation may offer an additional aid to diagnosis. A 44-year-old woman was admitted for elective endometrial ablation. She had no history of adverse drug reactions, and previous general anaesthetic procedures had been uneventful. Anaesthesia was induced with intravenous propofol (150 mg) and alfentanil (750 mg). Muscle relaxation was achieved with intravenous suxamethonium (100 mg). Within 1 min of intubation, the patient became cyanosed, with a heart rate of 45 beats/min. Cardiac arrest was diagnosed and cardiopulmonary resuscitation commenced. Surgery was cancelled, and the patient transferred to the intensive care unit. Laboratory results were as follows: mastcell tryptase, 1000 ng/ml; urinary methylhistamine, 86 ng/mmol creatinine; serum IgE, 1412 kU/l; suxamethoniumspecific IgE (RAST), 3. Skin prick testing, performed 5 weeks after the reaction, gave a positive reaction to suxamethonium (confirmed at 1:10 A dose/response expression of CD63 upon allergen challenge.
Databáze: OpenAIRE
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