The role of apitoxin in alleviating propionic acid-induced neurobehavioral impairments in rat pups: The expression pattern of Reelin gene
| Autor: | Maha H. Daghestani, Samah R. Khalil, Manar E Selim, Noura E. Abd El-Hameed, Enas N. Said, Yasmina M. Abd-Elhakim, Osama S. El-Tawil |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Serotonin Reelin Gene Cell Adhesion Molecules Neuronal Dopamine Down-Regulation Nerve Tissue Proteins Pharmacology Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Bee venom medicine Animals RNA Messenger Reelin Neurotransmitter gamma-Aminobutyric Acid Extracellular Matrix Proteins biology business.industry Serine Endopeptidases Brain General Medicine respiratory system Rats Apitoxin Bee Venoms Reelin Protein 030104 developmental biology chemistry biology.protein Female Nervous System Diseases Propionates business 030217 neurology & neurosurgery medicine.drug Social behavior |
| Zdroj: | Biomedicine & Pharmacotherapy. 93:48-56 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2017.06.034 |
| Popis: | The efficacy of apitoxin (bee venom; BV) in ameliorating propionic acid (PPA) -induced neurobehavioral impacts was studied. Sixty rat pups were enrolled in a split litter design to six groups: a control group, a PPA-treated group, a BV-treated group, a BV/PPA protective group, a PPA/BV therapeutic group, and a BV/PPA/BV protective and therapeutic group. Exploratory, social, locomotor, and repetitive/stereotype-like activities were assessed and prosocial, empathy, and acquired behavior were evaluated. Levels of neurotransmitter including serotonin, dopamine, and gamma-aminobutyric acid (GABA) were determined and a quantitative analysis of Reelin gene expression was performed. PPA treatment induced several behavioral alterations, as reduced exploratory activity and social behaviors, increased repetitive/stereotypic behaviors, and hyperactivity. In addition, a marked decline of neurotransmitters and down-regulation of Reelin mRNA expression were observed. BV exhibited high efficiency in ameliorating the PPA-induced neurobehavioral alterations, particularly when applied both before and after PPA administration. Overall, the results implied that BV has merit as a candidate therapeutic treatment to alleviate PPA-induced neurobehavioral disorders. |
| Databáze: | OpenAIRE |
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