Millitesla magnetic field effects on the photocycle of an animal cryptochrome
| Autor: | P. J. Hore, Kiminori Maeda, Jonathan G. Storey, Simon R. T. Neil, Dean M. W. Sheppard, Stefan Weber, Erik Schleicher, Jing Li, Kevin B. Henbest, Christiane R. Timmel, Stuart R. Mackenzie, Ryan Rodriguez, Till Biskup |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Photoperiod Flavin group Article 03 medical and health sciences Cryptochrome Animals Drosophila Proteins Eye Proteins Electron transfer reactions Multidisciplinary biology Chemistry Spectrum Analysis Tryptophan Absorption Radiation Magnetoreception biology.organism_classification Magnetic field Cryptochromes Drosophila melanogaster Magnetic Fields 030104 developmental biology Biophysics human activities Drosophila Protein |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Drosophila have been used as model organisms to explore both the biophysical mechanisms of animal magnetoreception and the possibility that weak, low-frequency anthropogenic electromagnetic fields may have biological consequences. In both cases, the presumed receptor is cryptochrome, a protein thought to be responsible for magnetic compass sensing in migratory birds and a variety of magnetic behavioural responses in insects. Here, we demonstrate that photo-induced electron transfer reactions in Drosophila melanogaster cryptochrome are indeed influenced by magnetic fields of a few millitesla. The form of the protein containing flavin and tryptophan radicals shows kinetics that differ markedly from those of closely related members of the cryptochrome–photolyase family. These differences and the magnetic sensitivity of Drosophila cryptochrome are interpreted in terms of the radical pair mechanism and a photocycle involving the recently discovered fourth tryptophan electron donor. |
| Databáze: | OpenAIRE |
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