Acyl group composition of metabolically active lipids in brain: variances among subcellular fractions and during postnatal development
| Autor: | Grace Y. Sun, Kwei Lee Su |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Phosphatidic Acids
Brain tissue Biology Phosphatidylinositols Biochemistry Diglycerides Cellular and Molecular Neuroscience chemistry.chemical_compound Myelin Mice medicine Animals Triglycerides Postnatal brain Brain Chemistry Fatty Acids Brain Metabolism Rat brain Lipid Metabolism Rats medicine.anatomical_structure chemistry Microsome Fatty Acids Unsaturated lipids (amino acids peptides and proteins) Composition (visual arts) Acyl group |
| Zdroj: | Journal of neurochemistry. 31(4) |
| ISSN: | 0022-3042 |
| Popis: | Using a combination of preparative TLC and GLC technique, the content and acyl group composition of diacyl-glycerophosphoinositols, diacyl-glycerophosphates, diacylglycerols and triacyl-glycerols in brain tissue were determined. The level of diacyl-glycerophosphoinositols in 40 day-old mouse brain was 2.7 μmol/g tissue as compared to 40–170 nmol/g for other minor lipids. The acyl groups of diacyl-glycerophosphoinositols were enriched in 18:0 and 20:4 (n-6). This characteristic acyl group profile was found in microsomes, synaptosomes, and in myelin. The acyl groups of diacyl-glycerophosphates and diacylglycerols were comprised mainly of 16:0, 18:0, 18:1 and 20:4 (n-6). In rat brain subcellular fractions, the acyl groups of diacylglycerols and diacyl-glycerophosphates in the microsomal fraction had a higher proportion of 22:6 (n-3) than those in the myelin and synaptosomal fractions. The acyl groups of the myelin lipids were higher in 18:l and lower in 20:4 (n-6) as compared to those in the microsomal and synaptosomal fractions. The triacylglycerols in brain exhibited an unusual acyl group profile which included small proportions of 14:0, 16:1, 20:4 (n-6), 22:4 (n-6) and 22:6 (n-3). Except for an increase in 18:1 and a corresponding decrease in 16:0 which was found in diacyl-glycerophosphoinositols, no apparent acyl group change was observed in other metabolically active lipids during postnatal brain development. |
| Databáze: | OpenAIRE |
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