Micronuclei and other nuclear anomalies in exfoliated buccal cells of urban solid waste collectors and recyclers in southern Brazil
| Autor: | Luciano Basso da Silva, Patrícia Ardenghi, Karisa Roxo Brina, Tiago Santos Carvalho |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Environmental Engineering Municipal solid waste Health Toxicology and Mutagenesis Binucleated cells Buccal swab 010501 environmental sciences Biology Solid Waste medicine.disease_cause 01 natural sciences Toxicology 03 medical and health sciences Occupational Exposure medicine Humans Environmental Chemistry Recycling 0105 earth and related environmental sciences Pollutant Micronucleus Tests Waste management Karyorrhexis Mouth Mucosa Public Health Environmental and Occupational Health General Medicine General Chemistry Pollution Refuse Disposal 030104 developmental biology Micronucleus test Micronucleus Brazil Genotoxicity |
| Zdroj: | Chemosphere. 193:1058-1062 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/j.chemosphere.2017.11.119 |
| Popis: | Workers involved in urban solid waste collection may be exposed to various environmental contaminants, including chemical pollutants, which might be mutagenic and increase the risk of diseases such as cancer. Evaluation of DNA damage in workers in this field are still scarce. This study aims to evaluate mutagenic and cytotoxic effects in workers involved in the collection and segregation of urban solid waste generated in southern Brazil. Municipal solid waste collectors were recruited in two municipalities of the state of Rio Grande do Sul. The control group was composed of workers of the education and commerce areas, with no exposure to known genotoxic agents. Slides of exfoliated buccal cells were analyzed to estimate the frequency of micronuclei (MN) as well as other nuclear abnormalities, such as broken-egg/bud, binucleation and karyorrhexis. The analyses of 44 workers and 45 control subjects have shown that the frequencies of MN, binucleated cells and karyorrhexis in the exposed workers were significantly higher than in the control group. In the exposed group, frequencies of MN and binucleated cells showed a significant positive correlation. The other cytogenetic parameters were not correlated among each other or with age and exposure time. These results indicate that the workers involved in urban solid waste collection are exposed to mutagenic and cytotoxic agents. |
| Databáze: | OpenAIRE |
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