Spirastrellolide B: Construction of the C(26)–C(40) Northern Hemisphere and a Related [5,5,7]-Bis-spiroketal Analogue

Autor:	Xiaozhao Wang, Amos B. Smith, Ningkun Li, Thomas J. Paxton
Rok vydání:	2012
Předmět:	chemistry.chemical_classification Molecular Structure Stereochemistry Organic Chemistry Northern Hemisphere Alkyne Marine Biology Stereoisomerism Biochemistry Article chemistry Spiro Compounds Spirastrellolide B Macrolides Physical and Theoretical Chemistry
Zdroj:	Organic Letters. 14:3998-4001
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol301795a
Popis:	Differential synthetic access to an advanced C26-C40 northern hemisphere fragment of spirastrellolide B and to a related [5,5,7]-bis-spiroketal analogue from a common intermediate has been achieved. Central to this venture is the regiocontrolled functionalization of a C(31-32) alkyne, exploiting different transition metal catalysts (cf. Pt(II) and Au(I)).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbb4884d9ba52d78d9b72c500e132ce https://doi.org/10.1021/ol301795a Zobrazit plný text záznamu