An evaluation of the use and handling errors of currently available recombinant human follicle-stimulating hormone pen injectors by women with infertility and fertility nurses
| Autor: | Francois Beckers, Salvatore Longobardi, Thomas D'Hooghe, Anke Seidler, Julian G. Martins, William MacGillivray |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Research design Infertility medicine.medical_specialty media_common.quotation_subject Nurses Pharmaceutical Science Fertility 02 engineering and technology PATIENT 030226 pharmacology & pharmacy simulated-use study VALIDATION Injections 03 medical and health sciences 0302 clinical medicine Recombinant human follicle stimulating hormone Humans Medication Errors Medicine Pharmacology & Pharmacy handling errors media_common Science & Technology business.industry GONAL-f pen injector Middle Aged CARE 021001 nanoscience & nanotechnology medicine.disease Patient preference Recombinant Proteins ALPHA Physical therapy Female Follicle Stimulating Hormone Human 0210 nano-technology business Life Sciences & Biomedicine r-hFSH patient preference |
| ISSN: | 1003-1014 |
| DOI: | 10.6084/m9.figshare.9609917 |
| Popis: | Background: This study compared preference ratings of women with infertility and nurses before and after simulated injection, and handling errors, with the GONAL-f®, Bemfola®, Ovaleap® and Rekovelle® pen injectors. Research design and methods: Injector-naïve women and injector-experienced fertility nurses tested injectors with masked labels in a randomized testing order. Injections were made into a foam pad and injectors were rated before and after use. Handling errors were recorded during the study. Ratings and errors were compared between pen injectors using ordinal or Poisson linear mixed models adjusted for testing order. Results: 120 women and 60 nurses participated. All participants tested GONAL-f and Bemfola injectors. Because of their similarity, participants tested either Rekovelle (71 women; 30 nurses) or Ovaleap (49 women; 30 nurses) injectors. The ratings from women were higher for GONAL-f vs other injectors after simulated use (p < 0.001 for all comparisons). Fertility nurses rated GONAL-f injector higher than other injectors both before and after use (p < 0.01 for all comparisons). Adjusted rates of total handling errors were lower with the GONAL-f vs other injectors (p < 0.001 for all comparisons) for both groups. Conclusions: GONAL-f injector was rated significantly higher than other injectors, which may be related to less handling errors observed with the GONAL-f injector. ispartof: EXPERT OPINION ON DRUG DELIVERY vol:16 issue:9 pages:1003-1014 ispartof: location:England status: published |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|