Evaluation of the influence of base and alkyl bromide on synthesis of pyrazinoic acid esters through fatorial design
| Autor: | João Paulo S. Fernandes, Lineu Prestes, Veni Maria Andres Felli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
chemistry.chemical_classification
Base (chemistry) medicine.drug_class esterification General Chemistry Factorial experiment Antimycobacterial lcsh:Chemistry chemistry.chemical_compound Pyrazinoic acid chemistry lcsh:QD1-999 Yield (chemistry) factorial design medicine antimycobacterial agent Organic chemistry Carboxylate Triethylamine Alkyl |
| Zdroj: | Química Nova, Volume: 32, Issue: 9, Pages: 2464-2466, Published: 2009 João Paulo dos Santos Fernandes ResearcherID Química Nova v.32 n.9 2009 Química Nova Sociedade Brasileira de Química (SBQ) instacron:SBQ Química Nova, Vol 32, Iss 9, Pp 2464-2466 (2009) |
| Popis: | Pyrazinoic acid esters have been synthesized as prodrugs of pyrazinoic acid. In the literature, its preparation is reported through the reaction of pyrazinoyl chloride with alcohols and the reaction with DCC/DMAP. In this work, it is reported a 2² factorial design to evaluate the preparation of these esters through the substitution of alkyl bromides with carboxylate anion. The controlled factors were alkyl chain length of bromides (ethyl and hexyl) and the used base (triethylamine and DBU). Results revealed that the used base used has significant effect on yield, and alkyl bromide used has neither significant influence, nor its interaction effect with base. |
| Databáze: | OpenAIRE |
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