Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions
| Autor: | Michael S. Hu, Leandra A. Barnes, Michael T. Longaker, Clement D. Marshall, H. Peter Lorenz, Tripp Leavitt |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Forum Editor: Michael Longaker (Part 2)Comprehensive Invited Review business.industry Basic science Regeneration (biology) Scars Critical Care and Intensive Care Medicine Bioinformatics Surgery 030207 dermatology & venereal diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Emergency Medicine Medicine Stem cell medicine.symptom business Wound healing Healthcare system |
| Zdroj: | Advances in Wound Care. 7:29-45 |
| ISSN: | 2162-1934 2162-1918 |
| DOI: | 10.1089/wound.2016.0696 |
| Popis: | Significance: Scarring of the skin from burns, surgery, and injury constitutes a major burden on the healthcare system. Patients affected by major scars, particularly children, suffer from long-term functional and psychological problems. Recent Advances: Scarring in humans is the end result of the wound healing process, which has evolved to rapidly repair injuries. Wound healing and scar formation are well described on the cellular and molecular levels, but truly effective molecular or cell-based antiscarring treatments still do not exist. Recent discoveries have clarified the role of skin stem cells and fibroblasts in the regeneration of injuries and formation of scar. Critical Issues: It will be important to show that new advances in the stem cell and fibroblast biology of scarring can be translated into therapies that prevent and reduce scarring in humans without major side effects. Future Directions: Novel therapies involving the use of purified human cells as well as agents that target specific cells... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|