Effector pathways regulating T cell activation
| Autor: | Jean Favero, Virginie Lafont |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Cell signaling
T-Lymphocytes T cell MAP Kinase Kinase 1 Receptors Antigen T-Cell Antigen-Presenting Cells Protein Serine-Threonine Kinases Lymphocyte Activation Major histocompatibility complex Biochemistry Jurkat Cells CD28 Antigens medicine Animals Humans Receptor Mitogen-Activated Protein Kinase Kinases Pharmacology Mitogen-Activated Protein Kinase 3 biology Effector T-cell receptor CD28 T lymphocyte Protein-Tyrosine Kinases Cell biology medicine.anatomical_structure Calcium-Calmodulin-Dependent Protein Kinases biology.protein Interleukin-2 Mitogen-Activated Protein Kinases Signal Transduction |
| Zdroj: | Biochemical Pharmacology. 56:1539-1547 |
| ISSN: | 0006-2952 |
| Popis: | Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T cell receptor antigen as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades acting in synergy and which culminate in activation of interleukin-2 gene transcription and eventually cell proliferation. Many studies aimed at characterizing these specific effector pathways have been published; however, the actual signaling molecules that transduce activation signals from the cell membrane to the nucleus and that directly regulate interleukin-2 gene transcription are not yet completely defined and remain a matter of debate. In this commentary, we have attempted to analyze the results, which are sometimes diverging if not totally contradictory, characterizing effector pathways that possibly are triggered during T cell activation. |
| Databáze: | OpenAIRE |
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