Diagnostic methods for neonatal hyperbilirubinemia
| Autor: | Christa M. Cobbaert, Aleš Dvořák, Paul W. Schenk, Christian V. Hulzebos, Eline A E van der Hagen, Libor Vítek, Claudio Tiribelli, Carlos D Coda Zabetta |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Diagnostic methods Bilirubin Total serum bilirubin In vitro diagnostic BILISTICK SYSTEM chemistry.chemical_compound PLASMA BILIRUBIN External quality assessment medicine GUNN RAT Intensive care medicine DIRECT SPECTROPHOTOMETRIC METHOD business.industry IX-ALPHA LETHAL MOUSE MODEL Gold standard (test) PERFORMANCE STANDARDIZATION chemistry Reference measurement Pediatrics Perinatology and Child Health SERUM BILIRUBIN Bilirubin levels business BRAIN BILIRUBIN LEVELS |
| Zdroj: | Pediatric Research, 90(2), 277-283. SPRINGERNATURE |
| ISSN: | 0031-3998 |
| Popis: | Invasive bilirubin measurements remain the gold standard for the diagnosis and treatment of infants with severe neonatal hyperbilirubinemia. The present paper describes different methods currently available to assess hyperbilirubinemia in newborn infants. Novel point-of-care bilirubin measurement methods, such as the BiliSpec and the Bilistick, would benefit many newborn infants, especially in low-income and middle-income countries where the access to costly multi-analyzer in vitro diagnostic instruments is limited. Total serum bilirubin test results should be accurate within permissible limits of measurement uncertainty to be fit for clinical purposes. This implies correct implementation of internationally endorsed reference measurement systems as well as participation in external quality assessment programs. Novel analytic methods may, apart from bilirubin, include the determination of bilirubin photoisomers and bilirubin oxidation products in blood and even in other biological matrices. IMPACT: Key message: Bilirubin measurements in blood remain the gold standard for diagnosis and treatment of severe neonatal hyperbilirubinemia (SNH). External quality assessment (EQA) plays an important role in revealing inaccuracies in diagnostic bilirubin measurements. What does this article add to the existing literature? We provide analytic performance data on total serum bilirubin (TSB) as measured during recent EQA surveys. We review novel diagnostic point-of-care (POC) bilirubin measurement methods and analytic methods for determining bilirubin levels in biological matrices other than blood. Impact: Manufacturers should make TSB test results traceable to the internationally endorsed total bilirubin reference measurement system and should ensure permissible limits of measurement uncertainty. |
| Databáze: | OpenAIRE |
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