From immunotoxicity to carcinogenicity: the effects of carbamate pesticides on the immune system

Autor: Soumaya Marzouki, Saloua El-Fazaa, Manel Jallouli, Mohamed Montassar Lasram, Alya Annabi, Najoua Gharbi, Ines Bini Dhouib
Přispěvatelé: Faculté des Sciences Mathématiques, Physiques et Naturelles de Tunis (FST), Université de Tunis El Manar (UTM), Université Arabe des Sciences [Tunis] (UAS), Laboratoire d'immunologie clinique [Institut Pasteur de Tunis], Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Allergy
Health
Toxicology and Mutagenesis
MESH: Immune System/drug effects
MESH: Carbamates/pharmacology
010501 environmental sciences
Lymphocyte Activation
medicine.disease_cause
01 natural sciences
Immune tolerance
03 medical and health sciences
Immune system
Animals
Humans
Environmental Chemistry
Medicine
Endocrine system
Immunotoxicity
MESH: Animals
Lymphocytes
Pesticides
Adverse effect
MESH: Lymphocyte Activation
Carcinogen
0105 earth and related environmental sciences
Cancer
MESH: Carcinogens/pharmacology
MESH: Humans
business.industry
Animal
MESH: Pesticides/pharmacology
General Medicine
Immune dysregulation
biochemical phenomena
metabolism
and nutrition
medicine.disease
Pollution
3. Good health
MESH: Lymphocytes/immunology
030104 developmental biology
Immunology
Carcinogens
MESH: Lymphocytes/drug effects
bacteria
Carbamates
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Human
Zdroj: Environmental Science and Pollution Research
Environmental Science and Pollution Research, Springer Verlag, 2016, 23 (10), pp.9448--9458. ⟨10.1007/s11356-016-6418-6⟩
ISSN: 0944-1344
1614-7499
Popis: International audience; The immune system can be the target of many chemicals, with potentially severe adverse effects on the host's health. In the literature, carbamate (CM) pesticides have been implicated in the increasing prevalence of diseases associated with alterations of the immune response, such as hypersensitivity reactions, some autoimmune diseases and cancers. CMs may initiate, facilitate, or exacerbate pathological immune processes, resulting in immunotoxicity by induction of mutations in genes coding for immunoregulatory factors and modifying immune tolerance. In the present study, direct immunotoxicity, endocrine disruption and inhibition of esterases activities have been introduced as the main mechanisms of CMs-induced immune dysregulation. Moreover, the evidence on the relationship between CM pesticide exposure, dysregulation of the immune system and predisposition to different types of cancers, allergies, autoimmune and infectious diseases is criticized. In addition, in this review, we will discuss the relationship between immunotoxicity and cancer, and the advances made toward understanding the basis of cancer immune evasion.
Databáze: OpenAIRE
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