Reversible protein aggregation as cytoprotective mechanism against heat stress
Autor: | Silvia Salas-Pino, Rafael R. Daga, Paola Gallardo |
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Přispěvatelé: | Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Junta de Andalucía |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Amyloid
Cytoplasm NUCLEAR Protein aggregation Biology Proteomics Fungal Proteins Protein Aggregates QUALITY-CONTROL Stress Physiological Transcription (biology) Yeasts Gene expression Genetics SHOCK RESPONSE Gene Cell Nucleus Mechanism (biology) GRANULES General Medicine Mini-Review Compartmentalization (psychology) INTRINSICALLY DISORDERED PROTEINS Stress Granules Solubility MOLECULAR CHAPERONES Cytoprotection AMYLOID FORMATION Biophysics PHASE-TRANSITION RNA Heat-Shock Response Intracellular Protein Binding MISFOLDED PROTEINS |
Zdroj: | Current Genetics |
ISSN: | 0172-8083 |
Popis: | © The Author(s) 2021. Temperature fluctuation is one of the most frequent threats to which organisms are exposed in nature. The activation of gene expression programs that trigger the transcription of heat stress-protective genes is the main cellular response to resist high temperatures. In addition, reversible accumulation and compartmentalization of thermosensitive proteins in high-order molecular assemblies are emerging as critical mechanisms to ensure cellular protection upon heat stress. Here, we summarize representative examples of membrane-less intracellular bodies formed upon heat stress in yeasts and human cells and highlight how protein aggregation can be turned into a cytoprotective mechanism. This work was supported by the Ministerio de Ciencia, Innovación y Universidades (Grant: PGC2018-099849-B-I00 to R.R. Daga) and Junta de Andalucía-FEDER-UPO (grant: UPO-1264663 to S.S.P.). |
Databáze: | OpenAIRE |
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