Ictal gamma-band interactions localize ictogenic nodes of the epileptic network in focal cortical dysplasia
| Autor: | Petr Marusic, Jaroslav Hlinka, Adam Kalina, Petr Jezdik, Alena Jahodova, Premysl Jiruska, Radek Janca, Pavel Krsek, Martin Kudr, Lenka Svobodova |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Drug Resistant Epilepsy Adolescent Network reconfiguration 050105 experimental psychology Young Adult 03 medical and health sciences Epilepsy 0302 clinical medicine Physiology (medical) medicine Gamma Rhythm Humans 0501 psychology and cognitive sciences Ictal Epilepsy surgery Child Retrospective Studies Cerebral Cortex business.industry 05 social sciences Middle Aged Cortical dysplasia medicine.disease Epileptogenic zone Intracranial eeg Sensory Systems Malformations of Cortical Development Neurology Female Neurology (clinical) Nerve Net business Neuroscience Gamma band 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Clinical Neurophysiology. 132:1927-1936 |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.clinph.2021.04.016 |
| Popis: | Epilepsy surgery fails in 30% of patients with focal cortical dysplasia (FCD). The seizure persistence after surgery can be attributed to the inability to precisely localize the tissue with an endogenous potential to generate seizures. In this study, we aimed to identify the critical components of the epileptic network that were actively involved in seizure genesis.The directed transfer function was applied to intracranial EEG recordings and the effective connectivity was determined with a high temporal and frequency resolution. Pre-ictal network properties were compared with ictal epochs to identify regions actively generating ictal activity and discriminate them from the areas of propagation.Analysis of 276 seizures from 30 patients revealed the existence of a seizure-related network reconfiguration in the gamma-band (25-170 Hz; p 0.005) - ictogenic nodes. Unlike seizure onset zone, resecting the majority of ictogenic nodes correlated with favorable outcomes (p 0.012).The prerequisite to successful epilepsy surgery is the accurate identification of brain areas from which seizures arise. We show that in FCD-related epilepsy, gamma-band network markers can reliably identify and distinguish ictogenic areas in macroelectrode recordings, improve intracranial EEG interpretation and better delineate the epileptogenic zone.Ictogenic nodes localize the critical parts of the epileptogenic tissue and increase the diagnostic yield of intracranial evaluation. |
| Databáze: | OpenAIRE |
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