Midlife income, occupation, APOE status, and dementia: a population-based study
| Autor: | Jaakko Tuomilehto, H. Soininen, T. Anttila, Aulikki Nissinen, Miia Kivipelto, Merja Hallikainen, Arto Mannermaa, Kari Alhainen, H. Heinonen, Eeva-Liisa Helkala |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Gerontology
Apolipoprotein E Male medicine.medical_specialty Population Apolipoprotein E4 Central nervous system disease Apolipoproteins E Risk Factors mental disorders Epidemiology Confidence Intervals Odds Ratio Medicine Dementia Humans Longitudinal Studies Risk factor Occupations education Socioeconomic status Poverty Aged education.field_of_study Chi-Square Distribution business.industry medicine.disease Population based study Cross-Sectional Studies Socioeconomic Factors Income Female Neurology (clinical) business Follow-Up Studies |
| Zdroj: | Neurology. 59(6) |
| ISSN: | 0028-3878 |
| Popis: | Objective: To examine the relationship between socioeconomic factors and APOE carrier status on the development of dementia. Methods: Subjects were derived from random, population-based samples previously studied in surveys carried out in 1972, 1977, 1982, and 1987. After an average follow-up of 21 years, 1449 (73%) subjects aged 65 to 79 years were re-examined in 1998. The diagnosis of dementia among the nonparticipants was derived from patient records of the local hospitals and primary health care clinics. Results: Low income level at old age was related to dementia, but low income level at midlife was not a risk factor for dementia. Dementia was also associated with decreasing income level, from midlife to old age 21 years later, when dementia was diagnosed. A sedentary occupation (office, service, or intellectual work) was associated with a decreased risk for dementia among participants; however, when the nonparticipants were included in the analysis, the associations were no longer significant. Low educational level and the APOE e4 allele independently increased the risk for dementia. Conclusions: Reduction in income level during follow-up and low income level at old age might be the consequence of a dementing process rather than being associated with risk evolution of dementia. |
| Databáze: | OpenAIRE |
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