The ACE gene and Alzheimer's disease susceptibility
| Autor: | Robert A. Furlong, Douglas F. Easton, Agustin G. Yip, Nigel J. Cairns, Yolanda Narain, David C. Rubinsztein, John Grimley Evans, Carol Brayne, John H. Xuereb, Margaret M. Esiri, Terence Murphy |
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| Rok vydání: | 2000 |
| Předmět: |
Apolipoprotein E
Male medicine.medical_specialty Genotype Short Report Biology Peptidyl-Dipeptidase A Apolipoproteins E Gene Frequency Alzheimer Disease Internal medicine Genetics medicine Odds Ratio Humans Genetic Predisposition to Disease Allele Risk factor Allele frequency Genetics (clinical) Alleles Aged Aged 80 and over Case-control study Angiotensin-converting enzyme Odds ratio Endocrinology biology.protein Female |
| Zdroj: | Journal of medical genetics. 37(9) |
| ISSN: | 1468-6244 |
| Popis: | A recent study suggested that the insertion (I) allele in intron 16 of the angiotensin converting enzyme gene (ACE) is associated with Alzheimer's disease (AD) risk. In our series of 239 necropsy confirmed late onset AD cases and 342 elderly non-demented controls aged >73 years, we found significantly different ACE genotype distributions in the case and control groups (p=0.007). Homozygotes for both the I and D alleles were associated with a higher risk compared to DI heterozygotes. While the APOE ε4 allele was strongly associated with AD risk in our series, we found no evidence for an interaction between the APOE and ACE loci. In addition, no interactions were observed between ACE and gender or age at death of the AD cases. A meta-analysis of all published reports (12 case-control series in total) suggested that both the II and ID ACE genotypes are associated with increased AD risk (odds ratio (OR) for II v DD 1.36, 95% confidence interval (CI)=1.13-1.63, OR for DI v DD 1.33, 95% CI=1.14-1.53, p=0.0002). Keywords: Alzheimer's disease; ACE gene; I allele |
| Databáze: | OpenAIRE |
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