Persistent low urinary excretion of 5-HIAA is a marker for favourable survival during follow-up in patients with disseminated midgut carcinoid tumours

Autor: Wendy Post, Thera P. Links, Anouk N A van der Horst-Schrivers, A N Machteld Wymenga, Ido P. Kema, Pax H.B. Willemse, Elisabeth G.E. de Vries
Přispěvatelé: Guided Treatment in Optimal Selected Cancer Patients (GUTS), Lifestyle Medicine (LM), Damage and Repair in Cancer Development and Cancer Treatment (DARE)
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Male
Cancer Research
Urine
Neuroendocrine tumors
Gastroenterology
chemistry.chemical_compound
urinary 5-HIAA level
Prospective Studies
SOMATOSTATIN ANALOG
Hazard ratio
Liver Neoplasms
gamma-Glutamyltransferase
Hydroxyindoleacetic Acid
Middle Aged
Prognosis
SOLID-PHASE EXTRACTION
Oncology
GASTROINTESTINAL-TRACT
Female
hormones
hormone substitutes
and hormone antagonists
PROGRESSION-FREE SURVIVAL
medicine.medical_specialty
Serotonin
Urinary system
Carcinoid Tumor
HEART-DISEASE
Biology
midgut carcinoid tumour
survival
LIVER METASTASES
Excretion
Internal medicine
Intestinal Neoplasms
medicine
Biomarkers
Tumor
Humans
Progression-free survival
DIGESTIVE ENDOCRINE TUMORS
Creatinine
prognostic factors
medicine.disease
Alkaline Phosphatase
Survival Analysis
Confidence interval
Endocrinology
chemistry
nervous system
ALKALINE-PHOSPHATASE
neuroendocrine tumours
NEUROENDOCRINE TUMORS
Zdroj: European Journal of Cancer, 43(18), 2651-2657. ELSEVIER SCI LTD
ISSN: 1879-0852
0959-8049
Popis: Survival of patients with disseminated midgut carcinoid tumours varies. We investigated which factors predict survival at referral and during follow-up, with emphasis on urinary 5-hydroxyindolacetic acid (5-HIAA) levels. Between 1992 and 2003, 76 patients were studied; urine was prospectively collected over a 24 h period every 3 months in order to measure 5-HIAA levels. Uni- and multivariate analyses were performed. Median follow-up was 55 months with a median survival of 54 months. Prognostic factors for poor survival were high age, high gamma-glutamyltransferase levels and greatly increased 5-HIAA levels (>20 mmol/mol creatinine) The Hazard Ratio (HR) of a greatly increased 5-HIAA level was 3.33 (95% confidence interval (CI) 1.66–6.66, p = 0.001). In a multivariate survival analysis with the 5-HIAA level as time dependent covariable, the HR for the 5-HIAA level was 1.007 (95% CI 1.004–1.010, p = 0.000). In conclusion, patients with persistent moderately increased urinary 5-HIAA levels (⩽ 20 mmol/mol creatinine) have favourable outcome.
Databáze: OpenAIRE
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