Clinical value of thymidine kinase and tissue polypeptide specific antigen in breast cancer
| Autor: | O. El-Ahmady, H. Khaled, O. Mansour, T. Motawi |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Oncology
medicine.medical_specialty Pathology Tissue Polypeptide Antigen Clinical Biochemistry Mammary gland Bone Neoplasms Breast Neoplasms Thymidine Kinase Efficacy Breast cancer Internal medicine Genetics medicine Biomarkers Tumor Humans Postoperative Period Stage (cooking) Molecular Biology Lymph node lcsh:R5-920 business.industry Biochemistry (medical) General Medicine medicine.disease Prognosis Tissue Polypeptide Specific Antigen Tamoxifen medicine.anatomical_structure Thymidine kinase Female business lcsh:Medicine (General) Mastectomy Radical Peptides |
| Zdroj: | Disease Markers, Vol 11, Iss 4, Pp 171-177 (1993) |
| ISSN: | 0278-0240 |
| Popis: | Thymidine kinase (TK) and tissue polypeptide specific antigen (TPS) were determined in breast cancer (BC) patients (n=83), normal healthy women (n=30) and 18 women with different benign mastopathies. Mean serum levels of TK and TPS in BC patients showed significant increases from their corresponding levels in healthy women and those with benign breast diseases. Diagnostic sensitivity of TK and TPS was 47% and 58% respectively at the selected cut-off values 8 VlL for TK and 110 U/L for TPS (96% specificity). Pre-operati ve serum levels of TK and TPS showed significant correlation with the stage of disease and with other classical prognostic factors; clinical stage, tumour size, lymph node involvement and distant metastasis. Nineteen BC patients were followed-up by serial monthly measurements of TK and TPS (4-10 samples). Both markers seemed to be valuable in monitoring drug efficacy. TK and TPS were able to detect systemic recurrence before clinical diagnosis (average 2 months lead time). TPS was greatly affected by liver diseases. |
| Databáze: | OpenAIRE |
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