Granular cell astrocytoma: report of a case and review of the literature
| Autor: | Lorenzo Bordi, Anna Maria Buccoliero, Chiara Caporalini, Silvia Scoccianti, Franco Ammannati, Gian Luigi Taddei, Luigi Pansini, Selene Moscardi, Antonella Simoni |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Pathology medicine.medical_specialty medicine.medical_treatment Central nervous system Peripheral edema Astrocytoma Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine medicine Biomarkers Tumor Humans Craniotomy Granular cell tumor Temozolomide medicine.diagnostic_test Glial fibrillary acidic protein biology business.industry Brain Neoplasms Magnetic resonance imaging General Medicine Middle Aged medicine.disease Immunohistochemistry medicine.anatomical_structure Neurology Granular Cell Tumor 030220 oncology & carcinogenesis biology.protein Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Clinical neuropathology. 35(4) |
| ISSN: | 0722-5091 |
| Popis: | A 54-year-old man with no remarkable past medical history was referred to our hospital for the appearance of generalized tonic clonic seizures with loss of consciousness, preceded by phosphenes at the right eye. On magnetic resonance imaging, a contrast-enhanced tumor in the left occipital lobe with peripheral edema was noted. He underwent craniotomy, and the entire mass was removed. Microscopic examination revealed infiltrative atypical astrocytes (glial fibrillary acidic protein, GFAP, positive) with discrete borders and granular cytoplasm. Ki-67 labeling index was 40%. The tumor was diagnosed as a high-grade granular cell astrocytoma (GCA). Postoperative radiotherapy combined with temozolomide was administered. GCAs are aggressive lesions and should not to be confused with localized, benign granular cell tumors or with other non neoplastic granular cell changes in the central nervous system (CNS). GCAs are rare tumors. At this time, only 63 supratentorial/ hemispheric cases, including our case, have been reported in literature. |
| Databáze: | OpenAIRE |
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