Heart failure associated with imported malaria: a nationwide Danish cohort study
| Autor: | Amil M. Shah, Lars Hviid, D Modin, G H Mohr, Christian Torp-Pedersen, Brian Claggett, Philip Brainin, Gunnar Gislason, Lasse S Vestergaard, Odilson Marcos Silvestre, Scott D. Solomon, Tor Biering-Sørensen, Jens-Ulrik Stæhr Jensen, Morten Schou, Lars Køber |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Epidemiology Denmark Population Heart failure Cohort Studies Young Adult Risk Factors Interquartile range Original Research Articles Internal medicine parasitic diseases medicine Humans Diseases of the circulatory (Cardiovascular) system Original Research Article Myocardial infarction education VIVAX education.field_of_study biology Proportional hazards model business.industry Plasmodium falciparum CARDIOVASCULAR INVOLVEMENT Middle Aged Prognosis medicine.disease biology.organism_classification Malaria RC666-701 Infectious diseases Female Cardiology and Cardiovascular Medicine business Cohort study |
| Zdroj: | Brainin, P, Mohr, G H, Modin, D, Claggett, B, Silvestre, O M, Shah, A, Vestergaard, L S, Jensen, J U S, Hviid, L, Torp-Pedersen, C, Køber, L, Solomon, S, Schou, M, Gislason, G H & Biering-Sørensen, T 2021, ' Heart failure associated with imported malaria : a nationwide Danish cohort study ', ESC Heart Failure, vol. 8, no. 5, pp. 3521-3529 . https://doi.org/10.1002/ehf2.13441 ESC Heart Failure, Vol 8, Iss 5, Pp 3521-3529 (2021) ESC Heart Failure Brainin, P, Mohr, G H, Modin, D, Claggett, B, Silvestre, O M, Shah, A, Vestergaard, L S, Jensen, J U S, Hviid, L, Torp-Pedersen, C, Kober, L, Solomon, S, Schou, M, Gislason, G H & Biering-Sorensen, T 2021, ' Heart failure associated with imported malaria : A nationwide Danish cohort study ', ESC heart failure, vol. 8, no. 5, pp. 3521-3529 . https://doi.org/10.1002/ehf2.13441 |
| ISSN: | 2055-5822 |
| Popis: | AIMS: Despite adequate treatment, recent studies have hypothesized that malaria may affect long-term cardiovascular function. We aimed to investigate the long-term risk of cardiovascular events and death in individuals with a history of imported malaria in Denmark.METHODS: Using nationwide Danish registries, we followed individuals with a history of malaria for the risk of incident heart failure (HF), myocardial infarction (MI), cardiovascular death and all-cause death (1 January 1994 to 1 January 2017). The population was age- and sex-matched with individuals without a history of malaria from the Danish population (ratio 1:9). We excluded patients with known HF and ischaemic heart disease at inclusion.RESULTS: We identified 3912 cases with a history of malaria (mean age 33 ± 17 years, 57% male, 41% Plasmodium falciparum infections). The median follow-up was 9.8 years (interquartile range 3.9-16.4 years). Event rates per 1000 person-years for individuals with a history vs. no history of malaria were HF: 1.84 vs. 1.32; MI: 1.28 vs. 1.30; cardiovascular death: 1.40 vs. 1.77; and all-cause death: 5.04 vs. 5.28. In Cox proportional hazards models adjusted for cardiovascular risk factors, concomitant pharmacotherapy, region of origin, household income and educational level, malaria was associated with HF (HR: 1.59 [1.21-2.09], P = 0.001), but not MI (HR: 1.00 [0.72-1.39], P = 1.00), cardiovascular death (HR: 1.00 [0.74-1.35], P = 0.98) or all-cause death (HR 1.11 [0.94-1.30], P = 0.21). Specifically, P. falciparum infection was associated with increased risk of HF (HR: 1.64 [1.14-2.36], P = 0.008).CONCLUSION: Individuals with a history of imported malaria, specifically P. falciparum, may have an increased risk of incident HF. |
| Databáze: | OpenAIRE |
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