Choroidal Changes Associated With Subretinal Drusenoid Deposits in Age-related Macular Degeneration Using Swept-source Optical Coherence Tomography
| Autor: | Demetrios G. Vavvas, Inês Laíns, John B Miller, Grayson W. Armstrong, Joan W. Miller, Shady Garas, Pedro Gil, Steven Mach, Joana Providência, Jay Wang, Ivana K. Kim, Rufino Silva, Patrícia Barreto, João Gil, Marco Marques, Deeba Husain |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty genetic structures Retinal Drusen 03 medical and health sciences 0302 clinical medicine Optical coherence tomography Surveys and Questionnaires Ophthalmology Age related medicine Humans Prospective Studies Fluorescein Angiography Aged Aged 80 and over medicine.diagnostic_test Choroid business.industry Diabetic retinopathy Macular degeneration medicine.disease Fluorescein angiography Choroidal Neovascularization eye diseases Cross-Sectional Studies 030104 developmental biology Choroidal neovascularization medicine.anatomical_structure Wet Macular Degeneration 030221 ophthalmology & optometry Optometry Female sense organs Tomography medicine.symptom business Tomography Optical Coherence |
| Zdroj: | American Journal of Ophthalmology. 180:55-63 |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/j.ajo.2017.05.021 |
| Popis: | Purpose To compare choroidal vascular features of eyes with and without subretinal drusenoid deposits (SDD), using swept-source optical coherence tomography (SS OCT). Design Multicenter, cross-sectional study. Methods We prospectively recruited patients with intermediate age-related macular degeneration (AMD), without other vitreoretinal pathology. All participants underwent complete ophthalmic examination, color fundus photography (used for AMD staging), and spectral-domain OCT (to evaluate the presence of SDD). SS OCT was used to obtain automatic macular choroidal thickness (CT) maps, according to the Early Treatment Diabetic Retinopathy Study (ETDRS) sectors. For data analysis, we considered mean choroidal thickness as the arithmetic mean value of the 9 ETDRS sectors. SS OCT en face images of choroidal vasculature were also captured and converted to binary images. Choroidal vascular density (CVD) was calculated as a percent area occupied by choroidal vessels in a 6-mm-diameter submacular circular. Choroidal vessel volume was calculated by multiplying the average CVD by macular area and CT. Multilevel mixed linear models (to account for the inclusion of 2 eyes of same subject) were performed for analysis. Results We included 186 eyes (n = 118 subjects), 94 (50.5%) presenting SDD. Multiple regression analysis revealed that, controlling for age, eyes with SDD presented a statistically thinner mean CT (s = −21.9, P = .006) and CT in all the individual ETDRS fields (s ≤ −18.79, P ≤ .026). Mean choroidal vessel volume was also significantly reduced in eyes with SDD (s = −0.003, P = .007). No significant associations were observed with mean CVD. Conclusion In subjects with intermediate AMD, choroidal thickness and vessel volume are reduced in the presence of subretinal drusenoid deposits. |
| Databáze: | OpenAIRE |
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