Stress-related noradrenergic activity prompts large-scale neural network reconfiguration
| Autor: | Shaozheng Qin, Erno J. Hermans, Marlieke T. R. van Kesteren, Mark Rijpkema, Lindsey Ossewaarde, Vincent C. Schoots, Guillén Fernández, Helena Cousijn, Marloes J. A. G. Henckens, Hein J. F. van Marle, Robert Oostenveld |
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| Přispěvatelé: | Educational Studies, Psychiatry, Department of Marketing Management, business school, emlyon, emlyon business school |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adrenergic Neurons
Male Hydrocortisone Nerve net Brain mapping cognitive neuroscience stress Norepinephrine 0302 clinical medicine 130 028 Probing the mechanistic underpinnings of stress-related memories Heart Rate 130 000 Cognitive Neurology & Memory Receptors hippocampus and memory [130 001 Bridging the gap] Perception and Action [DCN 1] Attention Non-U.S. Gov't [SHS.ECO] Humanities and Social Sciences/Economics and Finance ComputingMilieux_MISCELLANEOUS 0303 health sciences Brain Mapping Neurotransmitter Agents Multidisciplinary Research Support Non-U.S. Gov't Brain [SHS.ECO]Humanities and Social Sciences/Economics and Finance Magnetic Resonance Imaging 130 026 VENI Hermans ‘In a fit of fear’ medicine.anatomical_structure Adrenergic [SHS.GESTION]Humanities and Social Sciences/Business administration Female Locus Coeruleus [SHS.GESTION] Humanities and Social Sciences/Business administration Functional Neurogenomics [DCN 2] medicine.drug Adult medicine.medical_specialty Adolescent Thalamus Adrenergic beta-Antagonists Biology Research Support Autonomic Nervous System Amygdala Midbrain 03 medical and health sciences Young Adult SDG 3 - Good Health and Well-being Internal medicine Receptors Adrenergic beta medicine Journal Article Humans Saliva 030304 developmental biology Functional Neuroimaging 130 030 The schema-consolidation hypothesis Metyrapone Neurosecretory Systems Autonomic nervous system Affect Endocrinology Psychological Locus coeruleus beta Nerve Net alpha-Amylases Neuroscience 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | Science, 334(6059), 1151-3. American Association for the Advancement of Science Science, 334(6059), 1151-1153. American Association for the Advancement of Science Science, 334, 1151-3 Science Science, American Association for the Advancement of Science, 2011, 1151-1153 p Science, 334, 6059, pp. 1151-3 Hermans, E J, Van Marle, H J F, Ossewaarde, L, Henckens, M J A G, Qin, S, Van Kesteren, M T R, Schoots, V C, Cousijn, H, Rijpkema, M, Oostenveld, R & Fernández, G 2011, ' Stress-related noradrenergic activity prompts large-scale neural network reconfiguration ', Science, vol. 334, no. 6059, pp. 1151-1153 . https://doi.org/10.1126/science.1209603 Hermans, E J, van Marle, H J F, Ossewaarde, L, Henckens, M J A G, Qin, S, van Kesteren, M T R, Schoots, V C, Cousijn, H, Rijpkema, M, Oostenveld, R & Fernández, G 2011, ' Stress-related noradrenergic activity prompts large-scale neural network reconfiguration ', Science, vol. 334, no. 6059, pp. 1151-3 . https://doi.org/10.1126/science.1209603 |
| ISSN: | 0036-8075 1095-9203 |
| Popis: | Contains fulltext : 98369.pdf (Publisher’s version ) (Closed access) Contains fulltext : 98369.pdf (Author’s version postprint ) (Open Access) Acute stress shifts the brain into a state that fosters rapid defense mechanisms. Stress-related neuromodulators are thought to trigger this change by altering properties of large-scale neural populations throughout the brain. We investigated this brain-state shift in humans. During exposure to a fear-related acute stressor, responsiveness and interconnectivity within a network including cortical (frontoinsular, dorsal anterior cingulate, inferotemporal, and temporoparietal) and subcortical (amygdala, thalamus, hypothalamus, and midbrain) regions increased as a function of stress response magnitudes. beta-adrenergic receptor blockade, but not cortisol synthesis inhibition, diminished this increase. Thus, our findings reveal that noradrenergic activation during acute stress results in prolonged coupling within a distributed network that integrates information exchange between regions involved in autonomic-neuroendocrine control and vigilant attentional reorienting. |
| Databáze: | OpenAIRE |
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