Arylestarase and oxidative stress in operating room personnel
| Autor: | Necat Yilmaz, Nurullah Bülbüller, Hamit Yasar Ellidag, Neset Cerit, Asuman Arslan Onuk, Esin Eren |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Operating Rooms Health Personnel Medicine (miscellaneous) medicine.disease_cause General Biochemistry Genetics and Molecular Biology Arylesterase Cohort Studies Internal medicine Occupational Exposure Internal Medicine medicine Humans Pharmacology (medical) Prospective Studies Prospective cohort study Adverse effect Genetics (clinical) business.industry PON1 Surgery Oxidative Stress Reviews and References (medical) Cohort Anesthetics Inhalation Female Occupational exposure business Carboxylic Ester Hydrolases Oxidative stress Cohort study |
| Zdroj: | Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 23(1) |
| ISSN: | 1899-5276 |
| Popis: | Background. Long-term occupational exposure to trace concentrations of volatile anesthetics is known to have adverse effects on the health of exposed personnel. Objectives. We investigated paraoxonase-1 (PON1) and arylesterase (ARE), as well as antioxidant status (TAS) and total oxidant status (TOS) levels in anesthesia personnel (AP) who were chronically exposed to inhalation anesthetics, and compared them with levels in a control group. Material and Methods. We designed a comparative prospective study with 50 female subjects. The first cohort included 25 full-time female workers in operating rooms in two locations in the Antalya Education and Research Hospital in Antalya, Turkey. The control group was comprised of 25 female individuals working in the same hospitals without any work-related exposure to hazardous agents. Results. Serum ARE activity and TAS levels were significantly reduced (p = 0.04 and p < 0.0001, respectively), whereas TOS and OSI levels were found to be significantly higher (p = 0.01 and p < 0.0001, respectively) in AP. However, there were no significant differences in PON1 activity, PON1/HDL-C, ARE/HDL-C, and PON1/ /ARE (p = 0.30, p = 0.5, p = 0.1 and p = 0.7, respectively) when the two groups were contrasted. Conclusions. According to the results of this study, depending on the putative role of PON/ARE in oxidant stress-related diseases, particularly atherosclerosis and cancer, AP might be considered a risk group for the development of atherosclerosis and many other diseases (Adv Clin Exp Med 2014, 23, 1, 49–55). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|