Lesion of the nucleus basalis magnocellularis does not affect cerebral cortical blood flow in rats
| Autor: | Yukio Tateno, Toshiaki Irie, Hiroki Namba, Shuji Hasegawa, Kiyoshi Fukushi, Toshiro Yamasaki |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Pathology medicine.medical_specialty Central nervous system Striatum Biology Nucleus basalis Lesion chemistry.chemical_compound medicine Animals Cholinergic neuron Ibotenic Acid Cerebral Cortex General Neuroscience Amphetamines Rats Inbred Strains General Medicine Anatomy Vestibular Nuclei Iofetamine Corpus Striatum Rats Glucose medicine.anatomical_structure Cerebral blood flow chemistry Cerebral cortex Cerebrovascular Circulation Acetylcholinesterase medicine.symptom Ibotenic acid |
| Zdroj: | Neuroscience Research. 12:463-467 |
| ISSN: | 0168-0102 |
| DOI: | 10.1016/0168-0102(91)90079-e |
| Popis: | The effects of a unilateral ibotenic acid lesion of the nucleus basalis magnocellularis (NBM) on blood flow of the cerebral cortex and striatum were studied at 2, 4, 8 and 16 weeks after the lesion in conscious rats. In the cerebral cortex, no side-to-side difference in blood flow was observed, though cholinergic enzyme activity was markedly reduced on the side of the lesion. The results suggest that NBM lesion produces disturbance of cholinergic neurons in the cerebral cortex without significant alteration of blood flow. |
| Databáze: | OpenAIRE |
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