Basal ganglia dopamine loss due to defect in purine recycling
| Autor: | Suhail Kasim, Silaja Yitta, Kiyoshi Egami, Rosalinda C. Roberts, Hyder A. Jinnah, J. Chris Lewers, Mohamed Lehar |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Hypoxanthine Phosphoribosyltransferase Dopamine Presynaptic Terminals Biology Basal Ganglia Article lcsh:RC321-571 Cell Line Midbrain Mice Microscopy Electron Transmission Basal ganglia Neural Pathways medicine Animals Gliosis lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Mice Knockout Dopamine Plasma Membrane Transport Proteins Dopaminergic medicine.disease Mice Inbred C57BL Substantia Nigra Neurology nervous system Hypoxanthine-guanine phosphoribosyltransferase Purines Vesicular Monoamine Transport Proteins Knockout mouse Nerve Degeneration Female medicine.symptom Lesch–Nyhan syndrome Neuroscience medicine.drug |
| Zdroj: | Neurobiology of Disease, Vol 26, Iss 2, Pp 396-407 (2007) |
| ISSN: | 0969-9961 |
| Popis: | Several rare inherited disorders have provided valuable experiments of nature highlighting specific biological processes of particular importance to the survival or function of midbrain dopamine neurons. In both humans and mice, deficiency of hypoxanthine-guanine phosphoribosyl transferase (HPRT) is associated with profound loss of striatal dopamine, with relative preservation of other neurotransmitters. In the current studies of knockout mice, no morphological signs of abnormal development or degeneration were found in an exhaustive battery that included stereological and morphometric measures of midbrain dopamine neurons, electron microscopic studies of striatal axons and terminals, and stains for degeneration or gliosis. A novel culture model involving HPRT-deficient dopaminergic neurons also exhibited significant loss of dopamine without a morphological correlate. These results suggest that dopamine loss in HPRT deficiency has a biochemical rather than anatomical basis and imply that purine recycling to be a biochemical process of particular importance to the function of dopaminergic neurons. |
| Databáze: | OpenAIRE |
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