Study of the 5-HT2 antagonist ritanserin on sleep-waking cycle in the rat
| Autor: | Claude Gottesmann, Sandrine Silhol, Léon Glin |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Sleep waking Clinical Biochemistry Sleep REM Ritanserin Toxicology Biochemistry Behavioral Neuroscience Internal medicine medicine Animals Circadian rhythm Wakefulness Biological Psychiatry 5-HT receptor Pharmacology business.industry Electroencephalography Rats Inbred Strains Receptor antagonist Sleep in non-human animals Circadian Rhythm Rats Electrophysiology Endocrinology Anesthesia Serotonin Antagonists Sleep Stages Serotonin Sleep business psychological phenomena and processes medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 41:241-243 |
| ISSN: | 0091-3057 |
| Popis: | Ritanserin, a 5-HT2 receptor antagonist, was injected intraperitoneally to rats at light onset. It was found that 0.63 mg/kg decreased waking, increased the slow waves characteristic of the first stage of sleep, and decreased paradoxical sleep (PS) during the first four hours. Active waking was further decreased and slow wave stage increased during the following four hours. The number of synchronized and paradoxical sleep phases decreased whereas their duration increased during the first four hours. Ritanserin at 2.5 mg/kg decreased active waking and PS, whereas quiet waking and slow wave stage were increased during the first four hours. Quiet waking was increased during the following four hours. It is concluded that serotonin acting on 5 HT2 receptors is actively involved in sleep-waking regulation. |
| Databáze: | OpenAIRE |
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