Zebrafish models to study drug abuse-related phenotypes
| Autor: | Siddharth Gaikwad, Marco Elegante, Allan V. Kalueff, Eli Utterback, David Tien, Keith Wong, Nadine Wu, Evan J. Kyzar, Valerie Piet, Jonathan Cachat, Adam Stewart, Peter C. Hart |
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| Rok vydání: | 2011 |
| Předmět: |
Drug
animal structures Substance-Related Disorders media_common.quotation_subject Danio Pharmacology medicine Animals Humans Adverse effect Zebrafish media_common Study drug biology General Neuroscience Addiction fungi biology.organism_classification medicine.disease Phenotype Substance Withdrawal Syndrome Substance abuse Disease Models Animal Psychology Neuroscience |
| Zdroj: | revneuro. 22:95-105 |
| ISSN: | 2191-0200 0334-1763 |
| DOI: | 10.1515/rns.2011.011 |
| Popis: | Mounting evidence implicates the zebrafish (Danio rerio) as a promising model species for reward and addiction research. Modeling drug abuse-related behavior in both adult and larval zebrafish produced a wealth of clinically translatable data, also demonstrating their sensitivity to various drugs of abuse and the ability to develop tolerance. Several studies have also applied withdrawal paradigms to model the adverse effects of drug abuse in zebrafish. In this review, we summarize recent findings of a wide spectrum of zebrafish drug abuse-related behavioral and physiological phenotypes, discuss the existing challenges, and outline potential future directions of research in this field. |
| Databáze: | OpenAIRE |
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