Asphyxia and Hyaline Membrane Disease in Neonatal Monkeys
| Autor: | Sidney Cassin, Barry V. Kirkpatrick, Jack R Hessler, Donald V. Eitzman, Gonzalo Mantilla, William H. Donnelly |
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| Rok vydání: | 1985 |
| Předmět: |
Pathology
medicine.medical_specialty Amniotic fluid Hyaline Membrane Disease Physiology Gestational Age medicine Animals Humans Lung Hyaline Acidosis Asphyxia Asphyxia Neonatorum business.industry Infant Newborn Obstetrics and Gynecology Gestational age Pulmonary Surfactants Hydrogen-Ion Concentration Hypoxia (medical) Amniotic Fluid medicine.disease Macaca mulatta Sphingomyelins Perinatal asphyxia Disease Models Animal medicine.anatomical_structure Pediatrics Perinatology and Child Health Phosphatidylcholines Macaca medicine.symptom business |
| Zdroj: | American Journal of Perinatology. 2:101-107 |
| ISSN: | 1098-8785 0735-1631 |
| DOI: | 10.1055/s-2007-999924 |
| Popis: | An animal model for studying the relationship between perinatal asphyxia and hyaline membrane disease (HMD) is described. The HMD developed in these Macaca mulatta (rhesus) and M. arctoides (stump tail) monkeys was clinically, physiologically, and histologically similar to that seen in human infants. The monkeys were delivered by cesarean section at a gestational age of 85-91% of term when surfactant, though present, was less than mature levels. Asphyxia at birth proved to be an important factor in disease development. Five minutes of asphyxia immediately before the first breath greatly increased the incidence and severity of HMD when compared to nonasphyxiated controls of a similar gestational age. Amniotic fluid L/S ratios did not differ significantly in the asphyxiated and control groups but data based on static pressure-volume studies of the excised lungs indicated that the surfactant activity of the asphyxiated group was significantly less. Lung maturity with regard to surfactant production appears to be a critical factor. The data from these experiments, together with data cited in the literature, strongly suggest that the lung and its surfactant system is most vulnerable to hypoxia and/or acidosis during the early stages of surfactant production. The asphyxiated non-human primate model used here should prove valuable for studying the pathogenesis of HMD and especially for further clarifying the relationship between perinatal asphyxia and HMD. |
| Databáze: | OpenAIRE |
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