The extracellular matrix – the under‐recognized element in lung disease?

Autor: Jenny C Karlsson, Gunilla Westergren-Thorsson, Thais Mauad, Janette K. Burgess, Gavin Tjin
Rok vydání: 2016
Předmět:
collagen
Lung Diseases
0301 basic medicine
extracellular matrix
CELL-PROLIFERATION
lung
chronic obstructive pulmonary disease
Pathology and Forensic Medicine
Extracellular matrix
Pulmonary Disease
Chronic Obstructive
03 medical and health sciences
Idiopathic pulmonary fibrosis
AIRWAY SMOOTH-MUSCLE
Fibrosis
TGF beta signaling pathway
medicine
Humans
Invited Reviews
Glucocorticoids
Pathological
MILD ASTHMA
Extracellular Matrix Proteins
COPD
Invited Review
Lung
business.industry
fibrosis
TGF-BETA
IN-VITRO
asthma
respiratory system
medicine.disease
myofibroblast
Idiopathic Pulmonary Fibrosis
respiratory tract diseases
3. Good health
CONNECTIVE-TISSUE
ELASTIC FIBERS
niche
030104 developmental biology
medicine.anatomical_structure
PROTEOGLYCAN DEPOSITION
Immunology
IDIOPATHIC PULMONARY-FIBROSIS
RETICULAR BASEMENT-MEMBRANE
business
Myofibroblast
Zdroj: The Journal of Pathology
ISSN: 1096-9896
0022-3417
DOI: 10.1002/path.4808
Popis: The lung is composed of airways and lung parenchyma, and the extracellular matrix (ECM) contains the main building blocks of both components. The ECM provides physical support and stability to the lung, and as such it has in the past been regarded as an inert structure. More recent research has provided novel insights revealing that the ECM is also a bioactive environment that orchestrates the cellular responses in its environs. Changes in the ECM in the airway or parenchymal tissues are now recognized in the pathological profiles of many respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF). Only recently have we begun to investigate whether these ECM changes result from the disease process, or whether they constitute a driving factor that orchestrates the pathological outcomes. This review summarizes our current knowledge of the alterations in the ECM in asthma, COPD, and IPF, and the contributions of these alterations to the pathologies. Emerging data suggest that alterations in the composition, folding or rigidity of ECM proteins may alter the functional responses of cells within their environs, and in so doing change the pathological outcomes. These characteristics highlight potential avenues for targeting lung pathologies in the future. This may ultimately contribute to a better understanding of chronic lung diseases, and novel approaches for finding therapeutic solutions. © 2016 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Databáze: OpenAIRE
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