Cytokine polymorphisms and Alzheimer disease: possible associations
| Autor: | M. Megna, S. Barocci, S. Fiordoro, E. Ferrari, G. Ribizzi |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_treatment Dermatology Neuropsychological Tests Peptidyl-Dipeptidase A Biology Severity of Illness Index White People Pathogenesis Apolipoproteins E Alzheimer Disease Risk Factors Genotype medicine Humans Dementia Allele Gene Alleles Genetic Association Studies Aged Aged 80 and over Polymorphism Genetic Interleukins Mental Disorders Haplotype General Medicine Middle Aged medicine.disease Psychiatry and Mental health Cytokine Case-Control Studies Immunology Cytokines Female Neurology (clinical) Alzheimer's disease |
| Zdroj: | Neurological Sciences. 31:321-325 |
| ISSN: | 1590-3478 1590-1874 |
| DOI: | 10.1007/s10072-010-0221-9 |
| Popis: | Alzheimer’s disease (AD) is a degenerative dementia characterized by typical, destructive alterations of neurons (neurofibrillary tangles and amyloid plaques), and glial proliferation. Cytokine-driven inflammatory environment can contribute to the pathogenesis and/or progression of the disease. The aim of the study was to evaluate and compare genotypic and allelic polymorphisms of 13 cytokine genes in 19 Caucasoid AD patients with medium–high level of dementia (assessed by an MMSE |
| Databáze: | OpenAIRE |
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