A three-dimensional multipedal DNA walker for the ultrasensitive detection of tumor exosomes
| Autor: | Huizhen Wang, Dinggeng He, Kejing Wan, Kemin Wang, Yue Zhou, Jin Huang, Hong Cheng, Xiaoxiao He, Ruichen Jia |
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| Rok vydání: | 2020 |
| Předmět: |
Detection limit
Chemistry Aptamer High selectivity Metals and Alloys DNA walker Biosensing Techniques DNA General Chemistry Exosomes Exosome Catalysis Microvesicles Surfaces Coatings and Films Electronic Optical and Magnetic Materials Neoplasms Clinical diagnosis Materials Chemistry Ceramics and Composites Biophysics Humans Biosensor |
| Zdroj: | Chemical Communications. 56:12949-12952 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/d0cc04360e |
| Popis: | A three-dimensional (3D) multipedal DNA walker triggered by the specific recognition between aptamers and proteins was developed for ultrasensitive tumor exosome sensing. A detection limit of 1 particle μL-1 was obtained with high selectivity. With the advantages of being simple, cost-effective and ultrasensitive, the biosensor offers potential for the early clinical diagnosis of tumors. |
| Databáze: | OpenAIRE |
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