Early Kidney Graft Size and Doppler Parameters Are Associated With Kidney Graft Function 1 Year After Transplantation
| Autor: | Miha Arnol, Rafael Ponikvar, Senka Černe, Jadranka Buturović-Ponikvar, Andrej Bren, Aljoša Kandus |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Nephrology medicine.medical_specialty Diastole Urology Renal function Logistic regression Cohort Studies Internal medicine medicine Humans Retrospective Studies Transplantation business.industry Graft Survival Ultrasonography Doppler Middle Aged Kidney Transplantation medicine.anatomical_structure Cohort Regression Analysis Female Surgery Radiology business Body mass index Glomerular Filtration Rate Artery |
| Zdroj: | Transplantation Proceedings. 42:4026-4029 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2010.09.053 |
| Popis: | The aim of this study was to assess the association of various ultrasonography (US) and Doppler parameters of kidney graft as measured at 1 month posttransplant with 1-year graft function.The study cohort included 125 adult recipients of deceased donor kidney transplantations between January 2006 and February 2009. All patients underwent an US-Doppler examination performed by a trained nephrologist at 1 month posttransplant using an Acuson-Siemens Sequoia 512. Graft length and intrarenal Doppler indices were measured at the midsegmental artery level. Relative graft size was calculated by dividing graft length with body mass index. Graft function was assessed at 1 year by estimated glomerular filtration rate (eGFR) using the 4-variable Modification of Diet in Real Disease study equation. Linear and logistic regression analyses were used to assess the relationship between US-Doppler parameters and eGFR.Univariate linear regression showed a significant correlation between eGFR at 1 year and graft length at 1 month (P = .009), relative graft length0.50 cm per kg/m(2) (P = .004), resistance index0.75 (P = .031), and end-diastolic velocity9 cm/sec (P = .006). Logistic regression analyses showed that eGFR60 mL/min/1.73 m(2) at 1 year was significantly associated with graft length12 cm at 1 month (odds ratio [OR], 2.4; 95% confidence interval [CI], 1.16-4.92; P = .017), relative graft length0.5 cm per kg/m(2) (OR, 2.54; 95% CI, 1.20-5.35; P = .014), resistance index0.75 (OR, 2.86; 95% CI, 1.30-6.29; P = .009), and end-diastolic velocity9 cm/sec (OR, 2.37; 95% CI, 1.01-5.56; P = .047).In this retrospective analysis, kidney transplant recipients with greater graft length at 1 month, specifically when standardized to body size, showed better graft function at 1 year posttransplantation. Higher intrarenal diastolic blood flow and lower resistance index at 1 month were also predictive of better graft function at 1 year. |
| Databáze: | OpenAIRE |
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