Comparative study of sulpiride and haloperidol on dopamine turnover in the rat brain
| Autor: | Toshikiyo Shohmori, Kiyofumi Kobayashi, Yoshihide Imazu |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Levodopa 3 4-Dihydroxyphenylacetic acid Apomorphine Dopamine Striatum Nucleus accumbens Biochemistry Cellular and Molecular Neuroscience chemistry.chemical_compound Internal medicine medicine Haloperidol Animals business.industry Brain Rats Inbred Strains General Medicine Rats Endocrinology chemistry 3 4-Dihydroxyphenylacetic Acid Sulpiride business medicine.drug |
| Zdroj: | Neurochemical Research. 14:459-464 |
| ISSN: | 1573-6903 0364-3190 |
| DOI: | 10.1007/bf00964861 |
| Popis: | The effects of the neuroleptics, sulpiride and haloperidol, on dopamine (DA) turnover were compared following the acute and chronic administration of these drugs alone or in combination with levodopa or apomorphine. In the acute treatment, the increase in DA metabolites in the striatum and nucleus accumbens was more marked in the haloperidol-treated rats than in the sulpiride-treated rats. Following the additional administration of levodopa, however, the potency of the neuroleptics in elevating DA metabolites was reversed. A low dose of apomorphine induced a marked reduction in the striatal DA metabolite levels by approximately 50%. When rats were pretreated with the neuroleptics, haloperidol was more effective in preventing an apomorphine-induced reduction in DA metabolites. On repeated administration of the neuroleptics, a tolerance occurred in the striatum and nucleus accumbens, but not in the prefrontal cortex. This differential development of tolerance was observed in the different brain regions and with the different drugs administered. These results suggest that the pharmacological mechanism of sulpiride on DA turnover differs from that of haloperidol. |
| Databáze: | OpenAIRE |
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