Combined histochemical and biochemical demonstration of nigral vulnerability to lipid peroxidation induced by DOPA and iron
| Autor: | Shunsaku Hirai, Makoto Tanaka, Hiroko Kanai, Akemi Sotomatsu |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Iron medicine.medical_treatment Caudate nucleus Substantia nigra Deferoxamine Biology Iron Chelating Agents Lipid peroxidation chemistry.chemical_compound Internal medicine Basal ganglia medicine Animals Vitamin E Vitamin E Deficiency Rats Wistar General Neuroscience Putamen Dihydroxyphenylalanine Rats Adenosine Diphosphate Substantia Nigra Endocrinology nervous system Biochemistry chemistry Organ Specificity Lipid Peroxidation Vitamin E deficiency Caudate Nucleus |
| Zdroj: | Neuroscience Letters. 140:42-46 |
| ISSN: | 0304-3940 |
| Popis: | Using a newly developed lipid peroxidation-inducing system composed of DOPA and iron, we examined the vulnerability of substantia nigra to peroxidation in comparison with that of caudate-putamen obtained from normal or vitamin E-deficient animals. Histochemical detection of lipid peroxidation revealed that substantia nigra was far more susceptible than caudate putamen to DOPA and iron treatment, which was biochemically supported by measurements of thiobarbituric acid-reactive substances. Vitamin E deficiency accelerated such susceptibility of substantia nigra but had no influence on the histochemical findings observed in caudate-putamen. |
| Databáze: | OpenAIRE |
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